Indeed, further studies have shown that, unlike apoptosis, caspase-3 is not crucial for eryptotic cell death [84]
[DOI] [PMC free article] [PubMed] [Google Scholar] Grimm A., Eckert A
Such double therapeutic functions are hard to achieve by conventional non-catalytic antioxidants
Glutathione (GSH) is an endogenous tripeptide antioxidant that plays a key role in preventing oxidative stress, thereby preserving mitochondrial function and averting cellular apoptosis [10]
Additionally, alcohol itself is a major consumer of glutathione
Regulation of the arginine/NO pathway is paramount: while endothelial NO synthase (eNOS)-derived NO sustains cerebral blood flow by vasodilation, iNOS in activated glia overproduces NO, spawning neurotoxic peroxynitrite that exacerbates lipid peroxidation and mitochondrial dysfunction [201]